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The Research Ventures Catalyst (RVC) is a two-stage programme inviting proposals for new organisational models to tackle a research challenge. This application guidance is intended to support potential participants through the stage 1 open call process for the RVC scheme. Stage 1 The Department for Science, Innovation and Technology (DSIT) are initially inviting proposals and bids for up to £100,000 of ‘seed corn’ funding, which is available to support successful applicants in developing full plans for their new research ventures. We are looking for proposals that will bring together researchers1, experts and operators from different disciplines and sectors, or with complementary forms of technical expertise, to tackle a complex problem in a new organisational setting. The RVC aims to seed, and ultimately back with multi-million-multi-year funding, new partnerships and ways of working to address shared challenges. Stage 2 Successful applicants at stage 1...